I am running 285/45R22 and can only say that I love them. No issues with rubbing etc but you may do if you were to go for off road tyres, but not with standard road tyres.
I think they are the perfect size - sidewall but still responsive, fill the arches, good ride characteristics, readily available as a standard size (standard fit on L460 so can get LR OEM fitment).
In terms of gearing, I have a TDV6 and not noticed any negative effects in terms of acceleration etc. there is more than enough torque to handle a slightly larger tyre.
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